PENTACYCLIC TRITERPENOIDS WITH ANTIMICROBIAL ACTIVITY FROM THE LEAVES OF VERNONANTHURA PATENS (ASTERACEAE)

Patricia I. Manzano; Migdalia Miranda; Juan Abreu-Payrol; Mario Silva; Olov Sterner; Esther L. Peralta

doi:10.9755/ejfa.v25i7.15989

Authors

Patricia I. Manzano 1 Escuela Superior Politécnica del Litoral (ESPOL), Campus Gustavo Galindo, Prosperina. Km 30.5, Vía Perimetral, PO 09-01-586, Guayaquil, Ecuador
Migdalia Miranda Instituto de Farmacia y Alimentos. Universidad de La Habana, Calle 222 #2317, entre 23 y 27. La Coronela, La Lisa. Ciudad de La Habana, Cuba
Juan Abreu-Payrol 2 Instituto de Farmacia y Alimentos. Universidad de La Habana, Calle 222 #2317, entre 23 y 27. La Coronela, La Lisa. Ciudad de La Habana, Cuba
Mario Silva aboratorio de Productos Naturales. Facultad de Ciencias naturales y Oceanográficas. Universidad de Concepción, Box 160-C. Concepción, Chile
Olov Sterner 4 Centre for Analysis and Synthesis, Lund University, P.O. Box 124 SE-221 00, Lund, Sweden
Esther L. Peralta Escuela Superior Politécnica del Litoral (ESPOL), Campus Gustavo Galindo, Prosperina. Km 30.5, Vía Perimetral, PO 09-01-586, Guayaquil, Ecuador

DOI:

https://doi.org/10.9755/ejfa.v25i7.15989

Keywords:

Pentaciclyc triterpenoids, Lupeol, Epilupeol, Acetyl lupeol, Antimicrobial, Vernonanthura patens

Abstract

Vernonanthura patens (Kunth) H. Rob, is native to Mexico and South America and found in dry or wet forests or pine forests. They are reaching in height from 0 to 1865 meters above sea level (masl). They are distributed throughout South America, in Central America: Mexico, Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama, and northern South America: Venezuela, western South America: Bolivia, Colombia, Ecuador and Peru. Three pentacyclic triterpenoids from the leaves were isolated by chromatographic (Colum Chromatography (CC) and Thin Layer Chromatography (TLC)) techniques. The structures of these isolated compounds were identified by 1H NMR and 13C NMR spectroscopic and MS analysis as lupeol, epilupeol and acetyl lupeol. Lupeol and epilupeol showed antifungal activity against Fusarium oxysporum and Penicillium notatum, whereas acetyl lupeol was inactive.