HEPATOPROTECTIVE EFFECT OF ROSMARINUS OFFICINALIS AND ROSMARINIC ACID ON ACETAMINOPHEN-INDUCED LIVER DAMAGE

  • Rodrigo Lucarini Núcleo de Pesquisas em Ciências Exatas e Tecnológicas da Universidade de Franca, Avenida Dr. Armando Salles de Oliveira, 201 14404 600, Franca, SP, Brazil
  • Wagner Antonio Bernardes Núcleo de Pesquisas em Ciências Exatas e Tecnológicas da Universidade de Franca, Avenida Dr. Armando Salles de Oliveira, 201 14404 600, Franca, SP, Brazil
  • Marcos Gomide Tozatti Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP, Brazil
  • Ademar Alves da Silva Filho Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP, Brazil
  • Marcio Luis Andrade e Silva Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP, Brazil
  • Claudia Momo Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP, Brazil
  • Antonio Henrique Gomes Martins Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP, Brazil
  • Wilson Roberto Cunha Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP, Brazil

Abstract

The hydroalcoholic extract of the leaves of Rosmarinus officinalis (HE), a species of medicinal value, and its constituent rosmarinic acid (RA) were evaluated for hepatoprotective in the acetaminophen-induced liver damage model. Groups of Wistar albino rats (n=6) were pre-administered with HE (100, 250 and 500 mg/kg, p.o.) and RA (10, 25 and 50 mg/kg, p.o.) prior to a single dose of acetaminophen (APAP, 600 mg/kg body weight; p.o). The hepatoprotective activity of HE extract was observed through histopathological analysis and reduction of the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). These observations were comparable to the normal group prior to APAP administration. Group that was treated with APAP alone exhibited high levels of transaminases and ALP. The obtained results from the present study suggested that HE may prevent APAP-induced hepatic injuries. RA did not displayed significant hepatoprotective activity against APAP-induced liver damage.

Keywords: Rosemary, Hepatoprotective effect, Acetaminophen, Carnosol, Rosmarinic acid
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How to Cite
Lucarini, R., W. Bernardes, M. Tozatti, A. Filho, M. Silva, C. Momo, A. Martins, and W. Cunha. “HEPATOPROTECTIVE EFFECT OF ROSMARINUS OFFICINALIS AND ROSMARINIC ACID ON ACETAMINOPHEN-INDUCED LIVER DAMAGE”. Emirates Journal of Food and Agriculture, Vol. 26, no. 10, Sept. 2014, pp. 878-84, doi:https://doi.org/10.9755/ejfa.v26i10.17836. Accessed 25 June 2018.
Section
Regular Article